John Campbell on An Interesting Thing About Haemaglobin



High-altitude natives are an exceptional model for understanding the genetic and physiological bases of evolutionary adaptation. Species that are broadly distributed across altitudes can provide powerful insight into the genetic basis of high-altitude adaptation, because it is possible to examine segregating variation for phenotypes that may contribute to hypoxia tolerance. Recent research has identified many genes that appear to have experienced selection in high-altitude taxa, including genes thought to be involved in O2 transport, energy metabolism and hypoxia signalling (Simonson, 2015; Simonson et al., 2012; Storz and Cheviron, 2021). However, in most cases, the specific effects of these genetic variants on physiological function are poorly understood. … Identifying these functional effects has the potential to uncover novel and adaptive physiological mechanisms, given the growing appreciation that protein variants can have auxiliary effects that are unrelated to the ‘canonical’ function of the protein in question (Marden, 2013a).

Subscribe to Dr John Campbell.

Comments

Post a Comment

Popular posts from this blog

How Could One Unify CMU and MIT

Image
I mean, how to get the best of the two different philosophies of computation. One is based on typed programming languages and the other on engineering with diagrams . This is about practical computing and the cost and feasibility of software development in general. Here is the problem: We have a lot of algorithms which can all be described abstractly using some sort of pseudocode, or perhaps using some particular language (usually Python!). These algorithms are often well-studied and a lot is known about them in terms of their computational complexity in time and space. Substantive practical software systems invariably employ many such algorithms, often implemented in libraries with more or less well-specified APIs. But very few of these libraries are capable of interoperating because they are either packages written in some specific programming language like Java or Haskell, say, or they are written in C and used as object code, or they are written in an interpreted language like Sc...
Read more

Tensor Fields and Simplicial Complexes

Image
Listening to Freya Holmér last night I started to get glimmers of an idea I had long ago about how to represent vector spaces in computational processes using this recursive abstract type :  abstype 'a point = POINT   of {getx :  'a vector,       diff :  'a point -> 'a point,       move :  'a point -> 'a point,       scale : 'a -> 'a point,       proj :  'a point -> 'a} with    fun new i (op +) (op -) (op * ) dot =    let fun self x =  POINT       {getx = x,        move = fn (POINT pr) =>           (self (x + (#getx pr))),        diff = fn (POINT pr) =>          self (x - (#getx pr)),        scale = fn i =>          (self (x * i)),        proj = fn (POINT pr) =>     ...
Read more

HTML in Blog Posts

Just testing stuff: SVG You can click on the blue circle: MathML There is not much you can do with this. See Mathematical Markup Language 1.01 Specification   7.1.5 Mixing and Linking MathML and HTML . It's the big problem  of how you compose languages.   a x 2 + b x + c = 0 You can click on the discriminant: x = − b ± b 2 − 4 ⁢ a ⁢ c 2 ⁢ a 2D Canvas Sound  Beep! WebGPU Next level Parser expression grammar compiler:  https://peggyjs.org/online.html Devine Lu Linvega's unxtal assembler/debugger:  https://wiki.xxi...
Read more